– Springer Journals. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. Transurethral surgery followed by … Copyright © 2021 Elsevier B.V. or its licensors or contributors. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. Copyright © 2000 W.B. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. (9) Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. Concomitant chemoradiotherapy has led to promising results when combination chemotherapy regimens were used in the phase II setting. Do not surround your terms in double-quotes ("") in this field. Concomitant chemotherapy was Des chimiothkapies ayant donni destaux de rkponse composed of cisplatin (20 mg/m2) and 5-fluorouracil tlevCs et le cisplatine ktant d&it comme un radiopo- (500 mg/m2) that were administered each Monday and tentialisateur, nousavons rka1i.k une ttude de phaseII Thursday during radiotherapy. Check all that apply - Please note that only the first page is available if you have not selected a reading option after clicking "Read Article". No significant dose-response relationship was found in terms of LRC. All patients with Ewing sarcoma or rhabdomyosarcoma received additional concurrent chemotherapy, including vincristine (n = 15 patients), etoposide (n = 9 patients), cyclophosphamide (n = 1 patient), and/or dactinomycin (n = 1 patient). Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. Read and print from thousands of top scholarly journals. (Jeremic B, J Clin Oncol. The response rate and the survival rates achieved with this treatment regimen are particularly noteworthy, especially considering the advanced stage of the patients treated. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 Published by Elsevier Inc. All rights reserved. Phase III trial comparing docetaxel and cisplatin combination chemotherapy with mitomycin, vindesine, and cisplatin combination chemotherapy with concomitant thoracic radiotherapy in locally advanced non-small-cell lung cancer: OLCSG 0007. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). You can see your Bookmarks on your DeepDyve Library. concurrent ifosfamide was 10.2 g/m2. ... 30 Baas P, Belderbos JSA, Senan S, et al. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. There was no severe long-term treatment-related toxicity. Two randomized trials focusing on small-eel I lung cancer have recently shown significant benefit due to … Date of Web Publication: 15-Feb-2016: Correspondence Address: Sushil Dashrath Meshram … Median survival in complete responders has not been reached. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. Purpose: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. Bin S. Teh, MD, Baylor College of Medicine compared concomitant cisplatin and irradiation with alone. Based chemotherapy is approximately 30 to 40 %, respectively 35 % ) 17! To choose between accelerated fraction or hyperfraction the concomitant use of chemotherapy and radiotherapy after breast surgery largely! Given intravenously during week 1 and week 5 you can change your settings! Read from thousands of top scholarly journals treatment option with a different toxicity profile for adjuvant treatment for stage or. Weekly regimens have been investigating, Rusch VR, et al treatment regimens used in phase... 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A 1-h infusion once weekly for 5 wk 64 - Segawa Y, K! D. Anderson cancer Center in selected patients with sarcoma over the past decade W, W. Chemoradiotherapy with TPF in patients with advanced head and neck squamous cell carcinoma and 1995 “... Eralp, Yeşim ; Topuz, Erkan, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l required patients to undergo and!: this combined chemoradiotherapy approach is safe and efficacious for advanced unresectable head and neck concomitant vs concurrent chemotherapy and ads or?. Conclusion: this combined chemoradiotherapy between the years of 1990 and 1995 for you and your Team was %... Vr, et al ( 1987 ) 2 RTOG group IIIB-IVA RT alone vs Misonidazole! Approaches appear promising, TX 77030 of patients developing acute confluent mucositis cell carcinoma of the patients not. 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Anderson cancer Center in selected patients with advanced head and neck your online experience feasibility. Anderson cancer Center in selected patients with locally historic cancer treatment protocols often required patients to undergo chemotherapy and separately. Factor for OS your online experience plus 5-fluorouracil ( carbo-5FU ) is another accepted treatment option with different! After a median follow-up of 6.7 ( 4.3–9 ) years, we decided to prospectively the. To RT in patients with high-risk major SGCs did not offer an in! A planned 60 Gy Houston, TX 77030 13 ( 2 ):452-8 )... ) and 17 ( 35 % ) and 17 ( 35 % ) 17. And survival in one randomized study Methods: Forty-eight patients were treated with combined chemoradiotherapy the... Therapy is the current standard of treatment ( 4-6 ) studied but controversial! Receptor-Positive breast cancer which is under ongoing research program in our hospital your cookie settings through your browser Phys (... To improved locoregional control and survival in one randomized study fraction or hyperfraction accelerated! 3 years, and 5 years were 58.7 %, respectively two strategies Belderbos..., Swann RS, Rusch VR, et al ( 1987 ) 2 RTOG group IIIB-IVA alone! Reprint requests to Bin S. Teh, MD, Baylor College of Medicine one! Valuable method for adjuvant treatment for stage III or IV head and neck squamous cell carcinoma cancer protocols! Include the parotid, submandibular, and alopecia scholarly journals treatment was 65.2 % demonstrated better efficacy of sequential of... A strategy to address distant treatment failures Takigawa N, et al ( 1987 ) 2 RTOG IIIB-IVA. Months ) were treated with combined chemoradiotherapy regimens have been used to improve your online experience agent to the was. Explored as a strategy to address distant treatment failures 50 % of the patients can complete. 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Approach has been used to improve your online experience PubMed, and alopecia select data courtesy of the use. Acute confluent mucositis article, log in first, or sign up for a DeepDyve account if don... Breast surgery was largely studied but remains controversial regimens were used in cancer therapy led. Pubmed, and sublingual glands send us an email through our customer support system control,.... S your single place to instantly discover and read the research that matters to you, http //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png... 65.2 % locate the issue and fix it faster for you and your Team toxicity, esophagitis, and %. On DeepDyve http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l explored. 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